Glucocorticoid receptor contributes to the altered expression of hepatic cytochrome P450 upon cigarette smoking.
作者： Xue Li , Zhongfang Yan , Qi Wu , Xin Sun , Fan Li
关键词: Cancer research 、 Internal medicine 、 Downregulation and upregulation 、 Glucocorticoid receptor 、 Cytochrome P450 、 Autophagy 、 Drug metabolism 、 Receptor 、 Inflammation 、 Biology 、 Endocrinology 、 Nuclear receptor
摘要: Abstract Cigarette smoking has been shown to cause pathological alterations in the liver. However, how hepatic metabolism is altered during cigarette smoking‑induced inflammation remains be fully elucidated. In present study, a rat model of was established examine effects on inflammation, autophagy activity, and expression nuclear receptor CYP Elevated interleukin 1β activation liver were observed upon exposure rats. induced significant reduction mRNA levels cytochromes, including cytochrome P450 (Cyp)1A2, Cyp2D4 Cyp3A2. Accordingly, decrease also glucocorticoid (GR), regulator Cyp. Activation GR signal human LO2 cells did not affect autophagic genes, however, it led upregulation hCYP1A2, hCYP2C19 hCYP3A4, downregulation hCYP2C9. The antagonist, RU486, eliminated this effect, suggesting importance smoking.
sci-hub.se 参考文章(44)
Bryan Goodwin, Ecushla Hodgson, Daniel J. D'Costa, Graham R. Robertson, Christopher Liddle, Transcriptional regulation of the human CYP3A4 gene by the constitutive androstane receptor. Molecular Pharmacology. ,vol. 62, pp. 359- 365 ,(2002) , 10.1124/MOL.62.2.359
Clement Kleinstreuer, Yu Feng, Lung Deposition Analyses of Inhaled Toxic Aerosols in Conventional and Less Harmful Cigarette Smoke: A Review International Journal of Environmental Research and Public Health. ,vol. 10, pp. 4454- 4485 ,(2013) , 10.3390/IJERPH10094454
P. Moszczyński, Z. Żabiński, P. Moszczyński, J. Rutowski, S. Słowiński, Z. Tabarowski, Immunological findings in cigarette smokers. Toxicology Letters. ,vol. 118, pp. 121- 127 ,(2001) , 10.1016/S0378-4274(00)00270-8
Tajamul Hussain, Omar S. Al-Attas, Nasser M. Al-Daghri, Arif A. Mohammed, Edgard De Rosas, Shebl Ibrahim, Benjamin Vinodson, Mohammed G. Ansari, Khaled I. Alam El-Din, Induction of CYP1A1, CYP1A2, CYP1B1, increased oxidative stress and inflammation in the lung and liver tissues of rats exposed to incense smoke Molecular and Cellular Biochemistry. ,vol. 391, pp. 127- 136 ,(2014) , 10.1007/S11010-014-1995-5
Sabine Gerbal-Chaloin, Martine Daujat, Jean-Marc Pascussi, Lydiane Pichard-Garcia, Marie-Jose Vilarem, Patrick Maurel, Transcriptional regulation of CYP2C9 gene. Role of glucocorticoid receptor and constitutive androstane receptor. Journal of Biological Chemistry. ,vol. 277, pp. 209- 217 ,(2002) , 10.1074/JBC.M107228200
Annalisa Nannelli, Vera Chirulli, Vincenzo Longo, P. Giovanni Gervasi, Expression and induction by rifampicin of CAR- and PXR-regulated CYP2B and CYP3A in liver, kidney and airways of pig. Toxicology. ,vol. 252, pp. 105- 112 ,(2008) , 10.1016/J.TOX.2008.08.004
S. W. Ryter, A. M. K. Choi, Autophagy in the Lung Proceedings of the American Thoracic Society. ,vol. 7, pp. 13- 21 ,(2010) , 10.1513/PATS.200909-101JS
Christophe Corpechot, Farid Gaouar, Yves Chrétien, Catherine Johanet, Olivier Chazouillères, Raoul Poupon, Smoking as an independent risk factor of liver fibrosis in primary biliary cirrhosis Journal of Hepatology. ,vol. 56, pp. 218- 224 ,(2012) , 10.1016/J.JHEP.2011.03.031
Guillermo Mariño, Mireia Niso-Santano, Eric H. Baehrecke, Guido Kroemer, Self-consumption: the interplay of autophagy and apoptosis Nature Reviews Molecular Cell Biology. ,vol. 15, pp. 81- 94 ,(2014) , 10.1038/NRM3735
Lorenzo Azzalini, Elisabet Ferrer, Leandra N. Ramalho, Montserrat Moreno, Marlene Domínguez, Jordi Colmenero, Víctor I. Peinado, Joan A. Barberà, Vicente Arroyo, Pere Ginès, Joan Caballería, Ramón Bataller, Cigarette smoking exacerbates nonalcoholic fatty liver disease in obese rats Hepatology. ,vol. 51, pp. 1567- 1576 ,(2010) , 10.1002/HEP.23516