A comprehensive behavioral evaluation in the lithium-pilocarpine model in rats: effects of carisbamate administration during status epilepticus.

摘要: SummaryPurpose Administration of carisbamate during status epilepticus (SE) prevents the occurrence motor seizures in lithium–pilocarpine model and leads a subpopulation rats to spike-and-wave discharges characteristic absence epilepsy. Widespread neuroprotection accompanied this change seizure expression. To assess whether these carisbamate-induced changes affected comorbidity, we used large battery behavioral tests that had developed temporal lobe or absence-like seizures. Methods Lithium–pilocarpine saline was administered 60 adult rats. Carisbamate (90 mg/kg) diazepam given 1 h after SE onset, repeated 8 h later twice daily over 6 more days. Rats were video-monitored for 2 months. Subsequently, locomotor activity, anxiety, various types memory assessed. Key Findings In with seizures, treated not carisbamate, all features behavior impaired compared controls. exhibiting treatment behaved as controls paradigms tested along widespread neuroprotection. Significance Carisbamate leading instead impressively prevented comorbidities reported by patients epilepsy most disabling.