Age-Related Dynamics of the Main Extracellular Matrix Components in Residents of the Russian Arctic
作者： L. B. Kim , N. K. Belisheva , A. N. Putyatina , G. S. Russkih , P. M. Kozhin
DOI: 10.1134/S2079057017040075
关键词: Matrix metalloproteinase 、 Metabolism 、 Hydroxyproline 、 Fibronectin 、 Endocrinology 、 Fibrosis 、 Internal medicine 、 Age related 、 Chemistry 、 Glycosaminoglycan 、 Extracellular matrix 、 Gerontology 、 Geriatrics and Gerontology
摘要: The main extracellular matrix (EM) components in Arctic residents were studied. Northerners had increased levels of total glycosaminoglycans, hyaluronan, and collagen IV plasma both general peptide-bound hydroxyproline urine, which indicates an accelerated metabolism the as compared with Western Siberia. Age-related remodeling northerners manifested changed ratio quantity its components. Levels fibronectin, fractions age while level insignificantly. average positive correlation between biological indicators is suggestive a relationship these two processes: aging, on European North, pathological matrix, it associated aging. Changes local regulation system, including those related to metalloproteinases their tissue inhibitors, may be one reasons for matrix.
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