Vascular Zip Codes and Nanoparticle Targeting

摘要: The use of nanoparticles in medicine will require sensors that can serve as guidance molecules for targeting the particles to appropriate sites body. Another set be needed allow respond features at target, such inflammation, cell death, etc. Compounds target vascular endothelium provide one answer and sensing problems. blood vessels is readily accessible from stream, different tissues carry unique molecular signatures. Pathological lesions also put their signature on vasculature; tumors, both lymphatic differ normal vessels. Peptides antibodies recognize signatures have been shown useful directing therapeutic agents targets tumors. enhance efficacy therapy while reducing side effects. Combining technology with take us a step closer truly smart nanodevices.