Prostate Stem Cells in the Development of Benign Prostate Hyperplasia and Prostate Cancer: Emerging Role and Concepts
作者： Akhilesh Prajapati , Sharad Gupta , Bhavesh Mistry , Sarita Gupta , None
DOI: 10.1155/2013/107954
关键词: Pathology 、 Cancer stem cell 、 Prostate 、 Stem cell 、 Cancer research 、 Cell growth 、 Prostate cancer 、 Carcinoma 、 Medicine 、 Inflammation 、 Hyperplasia
摘要: Benign Prostate hyperplasia (BPH) and prostate cancer (PCa) are the most common prostatic disorders affecting elderly men. Multiple factors including hormonal imbalance, disruption of cell proliferation, apoptosis, chronic inflammation, aging thought to be responsible for pathophysiology these diseases. Both BPH PCa considered arisen from aberrant proliferation stem cells. Recent studies on have provided significant evidence origin diseases cells that share characteristics with normal Aberrant changes in regulatory may contribute development or PCa. Understanding provide insight into mechanisms convert quiescent adult proliferating compartments lead carcinoma. Ultimately, knowledge unique stem-like pathogenesis will facilitate new therapeutic targets In this review, we address recent progress towards understanding putative role complexities
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