Role of neurotrophic factors in cerebellar development
作者： DAN LINDHOLM , UTE ZIRRGIEBEL , AXEL LEINGÄRTNER , MARIA DA PENHA BERZAGHI , EERO CASTRÉN
DOI: 10.1016/B978-0-08-042527-6.50020-1
关键词: Neurogenesis 、 CXCL3 、 Granule (cell biology) 、 Neurotrophic factors 、 Neuroscience 、 Precursor cell 、 Efferent Neuron 、 Biology 、 Cerebellum 、 Mutant
摘要: Publisher Summary Development of the rodent cerebellum mainly occurs in postnatal stage and that provides an interesting model to study external factors influencing neurogenesis differentiation this brain region. The precursor cells cerebellar granule neurons proliferate layer (EGL) subsequently migrate inward reach internal (IGL). In molecular (ML), establish synaptic contacts with dendrites developing Purkinje are only efferent cerebellum. afferent input is conveyed by mossy fibers climbing make cells. There exist mutant mice exhibit disturbed development these animals have been studied understand a normal development. However, genetic defects unknown as possible involvement various neurotrophic therein.
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