Flu-like symptoms following botulinum toxin therapy.

摘要: This paper reviews the relevant literature on flu-like symptoms (FLS) in patients treated with botulinum toxin (BoNT) type A and B. We conducted a systematic search PubMed Medline of publications BoNT FLS. FLS were defined as presence an upper respiratory tract infection associated fever, general malaise or fatigue, within one month after injections not secondary to any other identified condition. have been reported between 1.7 20% various preparations BoNT/A. Most mild moderate lasting less than 2 weeks, but 66 serious AEs related Food Drug Administration 1989 2003. No significant differences frequency emerged when different BoNT/A commercial products compared, although no well-designed head-to-head comparison trials focusing published. For BoNT/B preparations, 5-55% cases. concluded that varies widely studies clear risk factors for this complication. suggest potential treatments like analgesics/antipyretics switching antigenic case persistent symptoms.