Cellular physiological approach for treatment of gastric cancer

摘要: Recent studies show that ion channels/transporters play important roles in fundamental cellular functions would be involved the cancer process. We review evidence for their expression and functioning human gastric (GC), evaluate potential of physiological approach clinical management. Various types channels, such as voltage-gated K(+) intracellular Cl(-) channels transient receptor have been found to express GC cells tissues, control cell cycles. With regard water aquaporin 3 5 an role progression GC. Regulators pH, anion exchanger, sodium-hydrogen vacuolar H(+)-ATPases carbonic anhydrases are also tumorigenesis Their pharmacological manipulation gene silencing affect behaviours, suggesting therapeutic targets Our indicate concentration could act a mediator signaling cycle cells. Further, we demonstrate cytocidal effects hypotonic shock on cells, blockade enhances these by inhibiting regulatory volume decrease. A deeper understanding molecular mechanisms may lead discovery approaches novel strategy