Cytokines in the serum and brain in mice infected with distinct species of Lyme disease Borrelia.

摘要: Abstract This study describes the detection of cytokines, interleukin-1 alpha (IL-1α), tumor necrosis-factor (TNFα) and interleukin-6 (IL-6) in serum brain homogenates susceptible resistant strains mice infected with distinct species/strains Borrelia . Significant elevation inflammatory cytokines was found sera C3H/HeN but not BALB/c on days 7 45 after inoculation. Brain were observed B. garinii afzelii production associated presence spirochetes. japonica only exception disease-susceptibility cytokine mice. These results suggest that there are differences pathogenic potential amongst strains, demonstrate a stronger response greater frequency recovery from than do