The genomic distribution of population substructure in four populations using 8,525 autosomal SNPs.

摘要: Understanding the nature of evolutionary relationships among persons and populations is important for efficient application genome science to biomedical research. We have analysed 8,525 autosomal single nucleotide polymorphisms (SNPs) in 84 individuals from four populations: African-American, European-American, Chinese Japanese. Individual were reconstructed using allele sharing distance neighbour-joining tree making method. Trees show clear clustering according population, with root branching African-American clade. The cluster much less star-like than European-American East Asian clusters, primarily because admixture. Furthermore, on branch, all ten together Japanese together. Using positional information, we demonstrate strong correlations between inter-marker both locus-specific FST (the proportion total variation due differentiation) levels branch lengths. Chromosomal maps distribution lengths constructed by combining these data other published SNP markers (total 33,704 SNPs). These clearly illustrate a non-uniform human genetic substructure, an instructional useful paradigm education