Correcting for Intra-Individual Variability in Sodium Excretion in Spot Urine Samples Does Not Improve the Ability to Predict 24 h Urinary Sodium Excretion.

摘要: Given a global focus on salt reduction efforts to reduce cardiovascular risk, it is important obtain accurate measures of intake population level. This study determined firstly whether adjustment for intra-individual variation in urinary sodium (Na) excretion using three repeated 24 h collections affects daily estimates and the use spot urine samples results better prediction Na compared single collection. Twenty community-dwelling men women from South Africa (mean age 59.7 years (SD = 15.6)) participating World Health Organization Study AGEing adult health (WHO-SAGE) Wave 3 collected early morning over consecutive days assess excretion. INTERSALT, Tanaka, Kawasaki equations, with either average or adjusted values, were used estimate these against measured Na. Adjustment was performed by ratio between-person (sb) total (sobs) variability obtained analysis variance. Sensitivity equations predict values below 5 g equivalent calculated. The sb/sobs 0.706 0.798, respectively. Correction variance × resulted contraction upper end distribution curve (90th centile: 157 136 mmoL/day; 95th 220 178 mmoL/day). All grossly over-estimated excretion, regardless corrected used. detect ≤5 g/day 13% while other two had zero sensitivity. Correcting contracted high intakes. Repeated collection does not improve accuracy predicting Spot are appropriate participants intakes recommended g/day.