Immobilized tumor necrosis factor-alpha muteins for enhancing immune response in mammals
作者： Mark Douglas Howell
DOI:
关键词: Immune system 、 Cell biology 、 Biology 、 Immunology 、 Biocompatible material 、 Biological fluids 、 Matrix (biology) 、 Tumor necrosis factor alpha 、 Tumor necrosis factor receptor
摘要: The present invention provides a method for enhancing an immune response in mammal to facilitate the elimination of chronic pathology. involves removal system inhibitors such as soluble TNF receptor from circulation mammal, thus, enabling more vigorous pathogenic agent. is accomplished by contacting biological fluids with one or binding partner(s) TNFα muteins capable and, depleting targeted inhibitor(s) fluids. Particularly useful absorbent matrix composed inert, biocompatible substrate joined covalently partner, mutein, specifically inhibitor receptor.
google.co.in 参考文章(226)
Chaker N. Adra, Bing Lim, Jean-Michel Lelias, Antibodies specific for HTm4 ,(1996)
Nadeau Rw, Gustavson Le, Oldfield Nf, Pharmacokinetics of teceleukin (recombinant human interleukin-2) after intravenous or subcutaneous administration to patients with cancer. Journal of biological response modifiers. ,vol. 8, pp. 440- ,(1989)
Obiri N, Emma D, Lackey A, O'Connor Te, Dupere S, Birch R, Yannelli J, Orr D, Patterns of cytokines released by peripheral blood leukocytes of normal donors and cancer patients during interleukin-2 activation in vitro. Journal of biological response modifiers. ,vol. 9, pp. 140- ,(1990)
Rabinowitz Ap, Mazumder A, Hu E, Watkins K, Hemolytic anemia in a cancer patient treated with recombinant interferon-gamma. Journal of biological response modifiers. ,vol. 9, pp. 256- ,(1990)
Hsiaoho Tung, Robert Hudak, Methods for preparing diagnostic reagents using antibody preparation ,(2001)
A. Mackensen, C. Galanos, Reinhard Andreesen, R. Engelhardt, Biological response to intravenously administered endotoxin in patients with advanced cancer Journal of biological response modifiers. ,vol. 9, pp. 480- ,(1990)
Lentz Mr, Continuous whole blood UltraPheresis procedure in patients with metastatic cancer. Journal of biological response modifiers. ,vol. 8, pp. 511- ,(1989)
X. Van Ostade, J. Tavernier, T. Prangé, W. Fiers, Localization of the active site of human tumour necrosis factor (hTNF) by mutational analysis. The EMBO Journal. ,vol. 10, pp. 827- 836 ,(1991) , 10.1002/J.1460-2075.1991.TB08015.X
C. Harold Mielke, Paul R. Sohmer, John C. Klock, Patrick J. Scannon, Method for treating plasma for transfusion ,(1984)