d‐Secoestrone derivatives. VI. 17β‐Benzyl‐17α‐hydroxy‐3‐methoxyestra‐1,3,5(10)‐trien‐16‐one
作者： Slobodanka Stanković , Dušan Lazar , Ljubica Medić-Mijačević , Katarina Penov-Gaši , Marija Sakač
DOI: 10.1107/S0108270101020807
关键词: D-secoestrone 、 Moiety 、 Ether 、 Molecule 、 Crystal structure 、 Hydroxy group 、 Hydrogen bond 、 Chemistry 、 Medicinal chemistry 、 Biological activity
摘要: The title molecule, C26H30O3, shows a novel chemical rearrangement of the substituents at position 17, i.e. an α-orientation hydroxy group and β-orientation bulky benzyl moiety. packing arrangement consists coils formed by O2⋯O3 hydrogen bonds along c axis. compound complete loss oestrogenic activity, neither does it exhibit antagonistic effect.
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