Methods of treating intestinal diseases and inflammatory conditions related to hiv-aids

摘要: Of the cytopathic retroviruses that affect mammals, including HIV-I, many selectively infect CD4+ T cells and cause immunosuppressive syndromes. These diseases destroy both thymus small large intestines, after infecting killing T-lineage in tissues. A mutant of murine leukemia retrovirus MoMuL V -TB, called tsl, causes this syndrome susceptible strains mice. In FVB/N strain mice are infected at birth, thymic atrophy, cell loss, intestinal collapse, body wasting, death occur by 30-40 days postinfection (dpi). Apoptosis ts1 -infected cells, thymus, peripheral lymphoid system intestines is caused accumulation tsl viral envelope preprotein gPr80env which inefficiently cleaved into mature proteins gp70 PrP 15E.