Distinct roles for visceral endoderm during embryonic mouse development.

摘要: The murine visceral endoderm is an extraembryonic cell layer that appears prior to gastrulation and performs critical functions during embryogenesis. traditional role ascribed the entails nutrient uptake transport. Besides synthesizing a number of specialized proteins facilitate uptake, digestion, secretion nutrients, coordinates blood differentiation vessel formation in adjoining mesoderm, thereby facilitating efficient exchange nutrients gases between mother embryo. Recent studies suggest addition this function overlying egg cylinder stage embryo plays active guiding early development. Cells anterior as organizer. Prior primitive streak, these cells express specific gene products specify fate underlying embryonic tissues. In review we highlight recent investigations demonstrating dual for provider both developmental cues