[Peroral long-term treatment of psoriasis using fumaric acid derivatives].

摘要: Oral treatment of psoriasis on an outpatient basis, using a preparation containing fumaric acid derivatives, was evaluated as initial monotherapy (3 months) and long-term basic therapy (12-14 in 13 11 patients, respectively. The course the disease analysed each individual case. After completion both parts trial, half patients that had only responded poorly to conventional antipsoriatic showed significant improvement which occurred after several weeks treatment. In 4 medication be stopped because abdominal pain. No severe side effects, particularly renal, hepatic or haematological nature, could established. Studies mice rats disclosed low acute toxicity derivatives used. additional analyses, hypotheses were dealt with concerning mechanism action psoriasis. To establish psoriasis, studies chronic pharmacokinetics will have conducted. Further clinical trials should evaluate single derivative instead mixtures.