Towards understanding the neurobiology of mammalian puberty:Genetic, genomic and proteomic approaches

摘要: The pubertal activation of gonadotropin hormone-releasing hormone (GnRH) release in rodents and primates is brought about by coordinated changes excitatory inhibitory inputs to GnRH neurons. These include both transsynaptic glia-to-neuron communication pathways. Using cellular molecular approaches combination with transgenic animal models high throughput procedures for gene discovery, we are beginning gain insights into the basic mechanisms underlying this dual transsynaptic/glial control secretion, hence, initiation mammalian puberty. results thus far obtained suggest that puberty requires reciprocal neuron-glia involving amino acids growth factors, synaptic make-up glia-neuron adhesiveness, transcriptional regulation genes required normal function neurons glial cells involved secretion.