Antiepileptic drugs and adverse skin reactions: An update

摘要: This paper summarizes current views on clinical manifestation, pathogenesis, prognosis and management of antiepileptic drug (AED)-induced adverse skin reactions. Cochrane Central Register Controlled Trials, MEDLINE (PubMed) ISI Web Knowledge were searched. The recent classification, among drug-induced injuries, points to Stevens-Johnson syndrome/toxic epidermal necrolysis (SJS/TEN), acute generalized exanthematous pustulosis hypersensitivity syndrome (HSS), which may be also recognized as a reaction with eosinophilia systemic symptoms (DRESS) or (DIHS). use aromatic AEDs, e.g. phenytoin, carbamazepine, oxcarbazepine, phenobarbital, primidone, zonisamide, lamotrigine is more frequently associated cutaneous eruption other signs hypersensitivity. There high degree cross-reactivity (40–80%) in patients allergic reactions AEDs. Pharmacogenetic variations biotransformation play role inducing these undesired effects. It suggested that avoidance specific AEDs populations at special risk, cautious dose titration careful monitoring response and, if applicable, laboratory parameters can minimize the serious consequences idiosyncratic