HIV Trafficking Between Blood and Semen During Early Untreated HIV Infection.

作者: Antoine Chaillon , Davey M. Smith , Christophe Vanpouille , Andrea Lisco , Parris Jordan

DOI: 10.1097/QAI.0000000000001156

关键词: SemenSex organPopulationVirusVirologyInflammationProinflammatory cytokineBiologyPeripheral blood mononuclear cellBlood plasma

摘要: Author(s): Chaillon, Antoine; Smith, Davey M; Vanpouille, Christophe; Lisco, Andrea; Jordan, Parris; Caballero, Gemma; Vargas, Milenka; Gianella, Sara; Mehta, Sanjay R | Abstract: BackgroundUnderstanding the dynamics of HIV across anatomic compartments is important to design effective eradication strategies. In this study, we evaluated viral trafficking between blood and semen during primary infection in 6 antiretroviral-naive men who have sex with men.MethodsDeep sequencing data env were generated from longitudinal plasma, peripheral mononuclear cells, seminal plasma samples. The presence or absence compartmentalization was assessed using tree-based Slatkin-Maddison distance-based Fst methods. Phylogeographic analyses performed a discrete Bayesian asymmetric approach diffusion Markov jump count estimation evaluate gene flow infection. Levels DNA human herpesviruses selected inflammatory cytokines also measured on genital secretions collected at baseline potential correlates increased migration compartments.ResultsWe detected varying degrees all individuals evaluated. None them maintained throughout analyzed time points. revealed that population circulating populated compartment earliest stages our limited set, found no association local inflammation herpesvirus shedding blood.ConclusionsThe early spread virus tract complex interplay these suggest efforts will require monitoring subpopulations sites course

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