Human CD1c+ dendritic cells secrete high levels of IL-12 and potently prime cytotoxic T-cell responses.
作者： Giulia Nizzoli , Jana Krietsch , Anja Weick , Svenja Steinfelder , Federica Facciotti
DOI: 10.1182/BLOOD-2013-04-495424
关键词: Cytotoxic T cell 、 Interleukin 12 、 Secretion 、 Cell growth 、 Cytotoxicity 、 Interferon gamma 、 CD8 、 Cell biology 、 Biology 、 Antigen presentation
摘要: Dendritic cells (DC) have the unique capacities to induce primary T-cell responses. In mice, CD8α+DC are specialized cross-prime CD8+ T and produce interleukin-12 (IL-12) that promotes cytotoxicity. Human BDCA-3+DC share several relevant characteristics with CD8α+DC, but of
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