Self nano-emulsifying simvastatin based tablets: design and in vitro/in vivo evaluation
作者： Ghada Abdelbary , Maha Amin , Salwa Salah
DOI: 10.3109/10837450.2012.672989
关键词: Bioavailability 、 Nano- 、 Simvastatin 、 Flow properties 、 Zeta potential 、 Materials science 、 Chromatography 、 In vitro in vivo 、 Pharmacokinetics 、 Water soluble drug
摘要: The aim of this work is to improve the oral bioavailability poorly water soluble drug, simvastatin (SV) through combining advantages self-nanoemulsifying systems (SNEs) and tablets. Ternary phase diagram was constructed using Labrafil, Tween 80 Transcutol, in order evaluate self-nanoemulsification domain. particle size distribution zeta potential prepared were evaluated Malvern Zetasizer. Liquisolid powders Aeroperl® as a coating material Avicel® or Starch 1500 carrier materials, powder flow properties then evaluated. Compressed SV SNE based tablets regarding their physical characteristics, in-vitro release well in-vivo pharmacokinetic evaluation six healthy human volunteers validated LC/MS/MS method. results revealed that developed improved significantly, compared commercially available (Zocor®). optimal...
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