Passive antibody therapy for infectious diseases

作者: Arturo Casadevall , Ekaterina Dadachova , Liise-anne Pirofski

DOI: 10.1038/NRMICRO974

关键词: Passive antibody therapyImmunizationAntimicrobialBiologyAntibodyThe RenaissanceBiological warfareImmunologyImmunityGeneral Immunology and Microbiology

摘要: Antibody-based therapies are currently undergoing a renaissance. After being developed and then largely abandoned in the twentieth century, many antibody preparations now clinical use. However, most of reagents that available target non-infectious diseases. Interest using antibodies to treat infectious diseases is fuelled by wide dissemination drug-resistant microorganisms, emergence new relative inefficacy antimicrobial drugs immunocompromised hosts fact antibody-based only means provide immediate immunity against biological weapons. Given need for recent technological advances field immunoglobulin research, there considerable optimism regarding renewed applications therapy prevention treatment

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