Rituximab in hematopoietic cell transplantation.

作者: Sally Arai , David B Miklos

DOI: 10.1517/14712598.2010.485982

关键词: ImmunologyB cellAutologous transplantationTransplantationMedicineTransplant ConditioningRituximabClinical trialStem cellGraft-versus-host disease

摘要: Importance of the field: The success rituximab therapy in managing B cell malignancies supports its widespread application both autologous and allogeneic hematopoietic transplantation.Areas covered this review: We searched PubMed database using terms rituximab, stem transplant, autologous, or limited search to clinical trials English. In total, 92 were identified 16 reviewed detail for significance intervention. review, we will examine rituximab's emerging roles in: i) vivo graft purging; ii) maintenance following transplantation; iii) transplant conditioning; iv) rationale use treatment/prevention chronic graft-versus-host disease post-transplant lymphoproliferative disorder.What reader gain: gain an understanding not only transplants malignancies, but also extension other diseases where are...

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