Decrease of EEG Coherence during hypoglycemia in type 1 diabetic subjects

摘要: Hypoglycemic events have been proven to be associated with measurable EEG changes. Several works in the literature evaluated these changes by considering approaches at single channel level, but multivariate analyses scarcely investigated Type 1 diabetes (T1D) subjects. The aim of present work is assess if and how hypoglycemia affects coherence a subset channels acquired hospital setting where eye- muscle activation-induced artifacts are virtually absent. In particular, multichannel data, 19 T1D hospitalized subjects undertaken an insulin-induced experiment, considered. Computation Partial Directed Coherence (PDC) through autoregressive models P3-A1A2, P4-A1A2, C3-A1A2 C4-A1A2 shows that decrease value coherence, most likely related progressive loss cognitive function altered cerebral activity, occurs when passing from eu- hypoglycemia, both theta ([4, 8] Hz) alpha ([8, 13] bands.