Bordetella pertussis Infection of Human Monocytes Inhibits Antigen-Dependent CD4 T Cell Proliferation

摘要: Human monocytes and macrophages bind Bordetella pertussis through multiple specific receptor-ligand interactions; however, the effect of these interactions on monocyte macrophage function is not well understood. In an in vitro system, B. infection human significantly impaired T cell proliferation to exogenous antigen at MOIs as low 1.0. isogenic mutant strains deficient filamentous hemagglutinin or adenylate cyclase toxin were incapable inhibition, suggesting that virulence-associated factors are essential for this activity. pertussis-induced death alone did explain results, nor differences intracellular survival. addition, alter phagocytosis complement-opsonized latex particles, indicating does globally impair functions system. These results suggest may be capable subverting cellular immune defenses infected host.