Immune cells in experimental acute kidney injury

摘要: The immune system has a vital role in the renal response to acute kidney injury (AKI). In this Review, Hye Ryoun Jang and Hamid Rabb describe current understanding of function innate adaptive systems early late phases ischaemic nephrotoxic AKI, influence cells on recovery long-term outcome following AKI. Acute (AKI) prolongs hospital stay increases mortality various clinical settings. Ischaemia–reperfusion (IRI), agents infection leading sepsis are among major causes Inflammatory responses substantially contribute overall damage Both involved inflammatory process occurring post-ischaemic Proinflammatory damage-associated molecular patterns, hypoxia-inducible factors, adhesion molecules, dysfunction vascular endothelium, chemokines, cytokines Toll-like receptors activation recruitment into injured kidneys. Immune both systems, such as neutrophils, dendritic cells, macrophages lymphocytes pathogenesis after IRI, some their subpopulations also participate repair process. These Experimental studies AKI have resulted improved mechanisms underlying will be foundation for development novel diagnostic therapeutic targets. This Review describes what is currently known about