Determining the clinical significance of coagulase-negative staphylococci isolated from blood cultures.

摘要: BACKGROUND AND OBJECTIVE: Coagulase-negative staphylococci are both an important cause of nosocomial bloodstream infections and the most common contaminants blood cultures. Judging clinical significance coagulase-negative is vital but often difficult can have a profound impact on institution’s infection rates. Our objective was to develop algorithm assist in determining staphylococci. DESIGN: A single experienced reviewer examined medical records 960 consecutive patients with positive cultures tertiar y-care referral teaching hospital. Four hundred five contained determination made performances various published algorithms that readily available laborator y data were compared. RESULTS: Eighty-nine (22%) episodes considered significant, whereas 316 contaminants. Patients bacteremia significantly more likely be neutropenic exhibit signs sepsis syndrome. The best combined sensitivity (62%) specificity (91%) for defined as at least two coagulasenegative within 5 days, or one culture plus evidence infection, which includes abnormal white cell count temperature pressure. CONCLUSION: Use this could potentially reduce misclassification inappropriate use vancomycin represent contamination (Infect Control Hosp Epidemiol 2005;26:559-566).