Mechanisms of Vessel Branching. Filopodia on Endothelial Tip Cells Lead the Way

作者: Frederik De Smet , Inmaculada Segura , Katrien De Bock , Philipp J. Hohensinner , Peter Carmeliet

DOI: 10.1161/ATVBAHA.109.185165

关键词: CellFilopodiaSprouting angiogenesisBiologyPseudopodiaMorphogenesisAnatomyEndothelial stem cellCell biologyExtracellular matrixAngiogenesis

摘要: … guided by endothelial tip cells. a, Original picture showing an embryonic endothelial tip cell … b, Confocal micrograph showing filopodia extensions at the leading tip cell (reprinted with …

参考文章(101)
Michael I Dorrell, Martin Friedlander, Edith Aguilar, Retinal Vascular Development Is Mediated by Endothelial Filopodia, a Preexisting Astrocytic Template and Specific R-Cadherin Adhesion Investigative Ophthalmology & Visual Science. ,vol. 43, pp. 3500- 3510 ,(2002)
Helen Sheldon, Maud Andre, John A. Legg, Paul Heal, John M. Herbert, Richard Sainson, Anshula S. Sharma, Jan K. Kitajewski, Victoria L. Heath, Roy Bicknell, Active involvement of Robo1 and Robo4 in filopodia formation and endothelial cell motility mediated via WASP and other actin nucleation-promoting factors The FASEB Journal. ,vol. 23, pp. 513- 522 ,(2009) , 10.1096/FJ.07-098269
Volkhard Lindner, Christina Booth, Igor Prudovsky, Deena Small, Thomas Maciag, Lucy Liaw, Members of the Jagged/Notch Gene Families Are Expressed in Injured Arteries and Regulate Cell Phenotype via Alterations in Cell Matrix and Cell-Cell Interaction American Journal of Pathology. ,vol. 159, pp. 875- 883 ,(2001) , 10.1016/S0002-9440(10)61763-4
Johan Dixelius, Taija Mäkinen, Maria Wirzenius, Marika J. Karkkainen, Christer Wernstedt, Kari Alitalo, Lena Claesson-Welsh, Ligand-induced Vascular Endothelial Growth Factor Receptor-3 (VEGFR-3) Heterodimerization with VEGFR-2 in Primary Lymphatic Endothelial Cells Regulates Tyrosine Phosphorylation Sites Journal of Biological Chemistry. ,vol. 278, pp. 40973- 40979 ,(2003) , 10.1074/JBC.M304499200
Laurent David, Christine Mallet, Michelle Keramidas, Noël Lamandé, Jean-Marie Gasc, Sophie Dupuis-Girod, Henri Plauchu, Jean-Jacques Feige, Sabine Bailly, Bone Morphogenetic Protein-9 Is a Circulating Vascular Quiescence Factor Circulation Research. ,vol. 102, pp. 914- 922 ,(2008) , 10.1161/CIRCRESAHA.107.165530
Thomas W. Chittenden, Filip Claes, Anthony A. Lanahan, Monica Autiero, Robert T. Palac, Eugene V. Tkachenko, Arye Elfenbein, Carmen Ruiz de Almodovar, Eduard Dedkov, Robert Tomanek, Weiming Li, Michael Westmore, JaiPal Singh, Arie Horowitz, Mary Jo Mulligan-Kehoe, Karen L. Moodie, Zhen W. Zhuang, Peter Carmeliet, Michael Simons, Selective Regulation of Arterial Branching Morphogenesis by Synectin Developmental Cell. ,vol. 10, pp. 783- 795 ,(2006) , 10.1016/J.DEVCEL.2006.03.012
Sascha Rutz, Benjamin Mordmüller, Seiji Sakano, Alexander Scheffold, Notch ligands Delta-like1, Delta-like4 and Jagged1 differentially regulate activation of peripheral T helper cells. European Journal of Immunology. ,vol. 35, pp. 2443- 2451 ,(2005) , 10.1002/EJI.200526294
S. Suchting, C. Freitas, F. le Noble, R. Benedito, C. Breant, A. Duarte, A. Eichmann, The Notch ligand Delta-like 4 negatively regulates endothelial tip cell formation and vessel branching Proceedings of the National Academy of Sciences of the United States of America. ,vol. 104, pp. 3225- 3230 ,(2007) , 10.1073/PNAS.0611177104
S. Estrach, J. Legg, F. M. Watt, Syntenin mediates Delta1-induced cohesiveness of epidermal stem cells in culture Journal of Cell Science. ,vol. 120, pp. 2944- 2952 ,(2007) , 10.1242/JCS.016253
Pipsa Saharinen, Lauri Eklund, Juho Miettinen, Riikka Wirkkala, Andrey Anisimov, Mark Winderlich, Astrid Nottebaum, Dietmar Vestweber, Urban Deutsch, Gou Young Koh, Bjorn R. Olsen, Kari Alitalo, Angiopoietins assemble distinct Tie2 signalling complexes in endothelial cell-cell and cell-matrix contacts. Nature Cell Biology. ,vol. 10, pp. 527- 537 ,(2008) , 10.1038/NCB1715