Microarray profile of differentially expressed genes in a monkey model of allergic asthma
作者： Jun Zou , Simon Young , Feng Zhu , Ferdous Gheyas , Susan Skeans
DOI: 10.1186/GB-2002-3-5-RESEARCH0020
关键词: Antigen 、 Biology 、 Microarray 、 Asthma 、 Bronchoconstriction 、 Immunology 、 Lung 、 Gene expression profiling 、 Ascaris suum 、 Inhalation
摘要: Background Inhalation of Ascaris suum antigen by allergic monkeys causes an immediate bronchoconstriction and delayed reaction, including a pulmonary inflammatory infiltrate. To identify genes involved in this process, the gene-expression pattern monkey lungs was profiled microarrays. Monkeys were challenged inhalation A. or given interleukin-4 (IL-4) treatment; lung tissue collected at 4, 18 24 h after challenge IL-4. Each compared to pool normal, unchallenged lungs.
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Noor A. Kalsheker, Alpha 1-antichymotrypsin. The International Journal of Biochemistry & Cell Biology. ,vol. 28, pp. 961- 964 ,(1996) , 10.1016/1357-2725(96)00032-5
Gilles Bleau, Frédéric Massicotte, Yannick Merlen, Chantale Boisvert, Mammalian chitinase-like proteins. EXS. ,vol. 87, pp. 211- 221 ,(1999) , 10.1007/978-3-0348-8757-1_15
R. P. Schleimer, B. S. Bochner, The role of adhesion molecules in allergic inflammation and their suitability as targets of antiallergic therapy. Clinical & Experimental Allergy. ,vol. 28, pp. 15- 23 ,(1998)
Sergij Goerdt, Oliver Politz, Vitam Kodelja, Constantin E. Orfanos, Nahid Hakij, Carola Müller, Alternative Macrophage Activation-Associated CC-Chemokine-1, a Novel Structural Homologue of Macrophage Inflammatory Protein-1α with a Th2-Associated Expression Pattern Journal of Immunology. ,vol. 160, pp. 1411- 1418 ,(1998)
Michelle Dziejman, Albert S. Iarossi, Alain Sauty, Kuldeep Neote, Rame A. Taha, Qutayba Hamid, Andrew D. Luster, Eduardo A. Garcia-Zepeda, The T Cell-Specific CXC Chemokines IP-10, Mig, and I-TAC Are Expressed by Activated Human Bronchial Epithelial Cells Journal of Immunology. ,vol. 162, pp. 3549- 3558 ,(1999)
R. H. Gundel, M. E. Gerritsen, G. J. Gleich, C. D. Wegner, Repeated antigen inhalation results in a prolonged airway eosinophilia and airway hyperresponsiveness in primates Journal of Applied Physiology. ,vol. 68, pp. 779- 786 ,(1990) , 10.1152/JAPPL.1990.68.2.779
Benfield Tl, Volck B, Price Pa, Sørensen O, Johansen Js, Nielsen Hj, Borregaard N, Calafat J, YKL-40, a mammalian member of the chitinase family, is a matrix protein of specific granules in human neutrophils. Proceedings of the Association of American Physicians. ,vol. 110, pp. 351- 360 ,(1998)
Shangming Zhang, Victoria A. Lawless, Mark H. Kaplan, Cytokine-Stimulated T Lymphocyte Proliferation Is Regulated by p27 Kip1 1 Journal of Immunology. ,vol. 165, pp. 6270- 6277 ,(2000) , 10.4049/JIMMUNOL.165.11.6270
Cristina Albanesi, Claudia Scarponi, Silvia Sebastiani, Andrea Cavani, Monica Federici, Ornella De Pità, Pietro Puddu, Giampiero Girolomoni, IL-4 Enhances Keratinocyte Expression of CXCR3 Agonistic Chemokines The Journal of Immunology. ,vol. 165, pp. 1395- 1402 ,(2000) , 10.4049/JIMMUNOL.165.3.1395
Pia Isomäki, Gregorio Aversa, Chia-Chun J. Chang, Reijo Luukkainen, Simo Nikkari, Paavo Toivanen, Jan E. de Vries, Juha Punnonen, Expression of soluble human signaling lymphocytic activation molecule in vivo The Journal of Allergy and Clinical Immunology. ,vol. 103, pp. 114- 118 ,(1999) , 10.1016/S0091-6749(99)70534-8