Copper/zinc superoxide dismutase, nuclear DNA content, and progression in human gliomas.
作者： Yoshihiko Yoshii , Atsushi Saito , D.W. Zhao , Tadao Nose
关键词: Cell cycle phase 、 Cancer research 、 Immunohistochemistry 、 Superoxide dismutase 、 Tumor progression 、 Clone (cell biology) 、 Oxidative stress 、 Flow cytometry 、 Chemotherapy 、 Pathology 、 Biology
摘要: To our knowledge, there have been no previous reports regarding the immunohistochemistry and image cytometry to demonstrate elevated Copper/zinc superoxide dismutase (Cu/Zn SOD) expression numbers of clonal cells in human gliomas. In 30 well-studied patients with gliomas, immunoreactivity for Cu/Zn SOD cytometric evidence DNA ploidy G2M cell cycle phase were evaluated from routinely prepared tissue blocks. positive tumor shown 8 13 glioblastomas (mean quantitative score; 1), 3 anaplastic gliomas (score; 0.6), none 9 low-grade The differences score was not significant. hypertetraploid glioblastomas, time progression shorter than while scores significantly different. same relationship held tetraploid specimens. Considering variables combination, high showed a short (p < 0.05) (1-5 months after radiotherapy chemotherapy) compared hypertetraploid, low-SOD or tetraploid, activity also tended be resistant anticancer drugs. Those results suggested that grade glioma single clone low effective associated oxidative stress, more two clones very less therapy. degree clonality should important factors influencing choice cytotoxic treatment.
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