Aflatoxin and hepatitis B virus biomarkers: a paradigm for complex environmental exposures and cancer risk.

摘要: The use of biomarkers in molecular epidemiology studies for identifying stages the progression development health effects environmental agents has potential providing important information critical regulatory, clinical and public problems. Investigations aflatoxins probably represents one most extensive data sets field this work may serve as a template future other agents. are naturally occurring mycotoxins found on foods such corn, peanuts, various nuts cottonseed they have been demonstrated to be carcinogenic many experimental models. As result nearly thirty years study, epidemiological human populations, aflatoxin B(1) was classified humans by International Agency Research Cancer. long-term goal research described herein is application preventative interventions populations at high-risk cancer. Several specific validated now being used intermediate prevention studies. these based upon knowledge biochemistry toxicology gleaned from both These subsequently utilised models provide modulation markers under different situations disease risk. This systematic approach provides encouragement preventive should development, validation chemical-specific cancer or chronic diseases.