Why cancer cells metastasize
作者： Xiao-Hui Zhang
DOI: 10.1016/J.MEHY.2013.01.022
关键词: Metastasis 、 Stem cell niche 、 Regeneration (biology) 、 Progenitor cell 、 Cellular differentiation 、 Tumor microenvironment 、 Cancer research 、 Immunology 、 Biology 、 Metastasis formation 、 Cancer cell
摘要: Metastasis is so complicated and well organized that there should be a good reason for it to happen. Here hypothesis proposed metastasis of cancer cells an abnormal form migration native stem/progenitor since derive from may inherit stemness, including ability. This intrinsic potential external cause mode. During metastasis, are involved in the cell recruitment meet need organism homeostasis, regeneration repair, mediated by signals using inherent mechanisms but leading catastrophic results. The "seed soil" can redefined as "soil" formed under certain circumstances "seed" attracted its particular "soil". Cancer microenviroment mimicking stem niche have superiority reactivity metastatic signals. And very few migrating metastases. conditions suitable formation still waiting revealed. tries explain why metastasize. It hoped examination this lead us real answer.
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