Molecular and Functional Characterization of Bacopa monniera: A Retrospective Review.
作者： Koilmani Emmanuvel Rajan , Jayakumar Preethi , Hemant K. Singh
DOI: 10.1155/2015/945217
关键词: Neuroscience 、 Bacopa 、 Acetylcholine 、 Bacopa monniera 、 Serotonin 、 Neuroplasticity 、 Dopamine 、 Serotonergic 、 Neuroprotection 、 Medicine
摘要: Over the last 50 years, laboratories around world analyzed pharmacological effect of Bacopa monniera extract in different dimensions, especially as a nerve tonic and memory enhancer. Studies animal model evidenced that treatment can attenuate dementia enhances memory. Further, they demonstrate primarily either acts via antioxidant mechanism (i.e., neuroprotection) or alters neurotransmitters (serotonin (5-hydroxytryptamine, 5-HT), dopamine (DA), acetylcholine (ACh), γ-aminobutyric acid (GABA)) to execute effect. Among them, 5-HT has been shown fine tune neural plasticity, which is substrate for formation. This review focuses on studies trace serotonergic system mediated key molecular changes are associated with
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