Complexity of mechanisms among human proprotein convertase subtilisin-kexin type 9 variants.
作者： Jacqueline S. Dron , Robert A. Hegele
DOI: 10.1097/MOL.0000000000000386
关键词: Kexin 、 Proprotein convertase 、 PCSK9 、 Ldl cholesterol 、 Genetics 、 Subtilisin 、 Biology
摘要: Purpose of reviewThere are many reports human variants in proprotein convertase subtilisin–kexin type 9 (PCSK9) that either gain-of-function (GOF) or loss-of-function (LOF), with downstream effects on LDL cholesterol and cardiovascular disease (CVD) risk. However, data particular mechanism
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