Understanding vitamin D metabolism in pregnancy: From physiology to pathophysiology and clinical outcomes.

摘要: This critical time frame of intrauterine life development is considered major importance on the metabolic imprinting overall health offspring, in later life. requires a delicate immune balance that nurtures allogeneic fetus, while maintaining reactivity against pathogens. Dysregulation these tightly controlled biophenomena at systemic and placental level, have been as potential mechanism mediating pathogenesis preeclampsia spontaneous birth. In this context, vitamin D has significant regulator both innate adaptive immunity by regulating cell proliferation, differentiation apoptosis. Vitamin metabolism during pregnancy manifests striking differences compared to non-pregnant state. Calcitriol increasing >2-3 fold first weeks whereas maternal 25-hydroxyvitamin crosses barrier represents main pool fetus. Moreover, pregnancy, receptor regulatory enzymes are expressed placenta decidua, indicating point immunomodulation maternal-fetal interface. Considering effects, hypovitaminosis associated with related disorders. review focuses mechanistic basis changes, background for disorders, discourse pathophysiology relating clinical outcomes.