Immunological effects of HIV-1 infection on the humoral response to malaria in an African population.

摘要: Abstract We conducted a cross-sectional study to determine the serological response malaria in an HIV-1 infected population and control region of high transmission. The group consisted 66 hospitalized patients with clinical acquired immunodeficiency syndrome (AIDS) 70 trauma without AIDS (controls). Mean optical densities antibody produced against RESA-4, RESA-8, RESA-11, (PNAN)5 (NAAG)5 synthetic peptides Plasmodium falciparum were compared between seropositive seronegative using non-parametric statistics. had significantly less P. ring stage peptide, RESA-8 (P = 0.001), than comparable patients. Antibody levels also low for other peptides, RESA-4 0.024) RESA-11 0.024). Although not statistically significant, among higher During infection, polyclonal B cell activation may occur as noted patients, but increased immunosuppression advanced AIDS, stimulation appears be diminished. This results decreased production antibody.