Factors predicting missing instruments in three cancer randomized clinical trials.

摘要: Missing patient-reported outcome (PRO) data can seriously threaten the validity of randomized clinical trials (RCTs). Identifying which factors predict missing instruments may help researchers develop strategies to prevent it from happening. This study examined association with time first instrument after randomization in three cooperative group RCTs. We performed descriptive analyses and Cox proportional hazards regressions for RCTs selected Canadian Cancer Trials Group: MA17 (breast cancer), PR7 (prostate LY12 (non-Hodgkin’s lymphoma). The was instrument. Variables 15 were used as covariates based on availability previously-reported putative associations PRO data. Nine percent 1352 subjects MA17, 37% 923 PR7, 59% 477 had a Twenty-five within 4.6 years. median was: not observed 7.3 years 0.12 years LY12. regression revealed statistically significant independent only five factors: baseline age (PR7) level well-being (LY12), centre activity presence post-graduate residency training program (MA17, PR7), geographic location (PR7, LY12). Many reported have do seem Context is important understanding few that may.