Evolutionary evidence on suitability of S ec D as a target for development of antibacterial agents against S taphylococcus aureus

摘要: Staphylococcus aureus causes many infections and its drug resistance is a worrying challenge for medical care. The SecD subunit of Sec secretion system in methicillin-resistant S. aureus an attractive target because dysfunction leads to the death bacteria as more efficient than SecA SecF. Evolution could have made become insensitive antibacterial agents although drugs directly against yet develop. So far, no detailed information on evolution has been available, thus 2686 sequences with full taxonomic from kingdom species were analyzed. First, variance pairwise p-distance was evaluated each group. Second, further partitioned into intergroup intragroup variances quantification horizontal vertical gene transfer. Third, phylogenetic tree built trace evolutionary pathway. results showed that overall SecDs appears undergone Only 0.5% transfers found between any two S. aureus, 6.8% 8.8% different same species, only one located far away sister cluster. Thus, statistic analyses demonstrate staphylococcus small chance mutating, provide evidence use potential new generation S. aureus.