Determinants of patient adherence: a review of systematic reviews

摘要: Purpose: A number of potential determinants medication non-adherence has been described so far. However, heterogenic quality existing publications poses the need for use rigorous methodology in building a list such determinants. The purpose this study was systematic review current research on patient adherence grounds recently agreed European consensus taxonomy and terminology. Methods: MEDLINE, EMBASE, CINAHL, Cochrane Library, IPA, PsycINFO were systematically searched reviews published between 2000/01/01 2009/12/31 that provided to medication. searches limited papers having prescribed by health professionals outpatient as major topic. Results: 51 included review, covering 19 different disease categories. In these studies, exclusively assessing chronic therapies, 771 individual factor items identified, which most implementation, only 47 - persistence with Factors unambiguous effect further grouped 8 clusters socio-economic-related factors, 6 healthcare team- system-related condition-related 7 therapy-related 14 patient-related factors. lack standardized definitions poor measurement methods resulted many inconsistencies. Conclusions: This provides clear evidence is affected multiple Therefore prediction patients difficult. Consequently, suitable multifaceted interventions may be effective answer toward unsatisfactory adherence. Limited medication, those providing short-term treatment identify areas future research.