The polycystic ovary syndrome (pcos) status and cardiovascular risk in young women

摘要: The study investigated the presence of early vascular damage and chronic inflammation, their relationships with hormonal metabolic parameters in 45 young women PCOS comparison thirty-two healthy age-matched controls. Hormonal profiles, high sensitivity C-reactive protein (hsCRP), tumoral necrosis factor-alpha (TNF-α), endothelin-1 (ET-1), brachial flow-mediated vasodilation (FMD) carotid intima-media thickness (CIMT) were determined both groups. Compared controls, had significantly lower FMD respectively higher ET-1 levels (p=0.001). No differences observed between groups terms CIMT or inflammatory markers. In group, correlated only testosterone concentrations (r = 0.31, p 0.037), whereas hsCRP independently predicted by body mass index (BMI). Within total status was sole significant predictor independent FMD. conclusion, there is evidence endothelial dysfunction associated increased androgen hormones PCOS. combination coexistent obesity promoting inflammation contributes to progression atherogenesis should be regarded as a marker cardiovascular risk, along well-known risk factors.