Effects of desmopressin on the sleep of children suffering from enuresis
作者： C Rahm , S Schulz-Juergensen , P Eggert
DOI: 10.1111/J.1651-2227.2010.01724.X
关键词: Placebo 、 Anesthesia 、 Desmopressin 、 Polysomnography 、 Enuresis 、 Medicine 、 Bed-wetting 、 Sleep Stages 、 Arousal 、 Sleep in non-human animals
摘要: Aim: To evaluate the effect of 1-desamino-8-D-Arginine Vasopressin (DDAVP) on sleep architecture and arousal reactions in children with primary monosymptomatic nocturnal enuresis (PME). Methods: A prospective, placebo-controlled, randomized, double-blind, cross-over study was performed suffering from bed-wetting. Placebo DDAVP were given for 7 days each after which an unattended home polysomnography (PSG) recorded. After lifting blinding, PSGs compared. Results: total 20 PME, aged 6–15 years, enrolled study. The number wet nights decreased significantly treatment. Delta power, distribution stages, arousals, index arousals stages did not differ significantly. Bed-wetting occurred within stage follow any particular pattern. In most cases, it preceded by reaction, but no awakening occurred. Conclusion: has PME when analysed classical PSG, is determined collecting electric activity cortical neurons. Taking recent research findings into account, this supports thesis that disturbances causing occur at brain stem level do reach consciousness.
sci-hub.se 参考文章(28)
Gaby Bader, Tryggve Nevéus, Sonja Kruse, Ulla Sillén, Sleep of primary enuretic children and controls Sleep. ,vol. 25, pp. 579- 583 ,(2002) , 10.1093/SLEEP/25.5.573
P. Eggert, K. Chavez-Kattau, D. Müller, [Age- and weight-related dosage of dDAVP in the treatment of primary nocturnal enuresis]. Klinische Padiatrie. ,vol. 213, pp. 317- 320 ,(2001) , 10.1055/S-2001-18458
R. J. Broughton, Sleep Disorders: Disorders of Arousal?: Enuresis, somnambulism, and nightmares occur in confusional states of arousal, not in "dreaming sleep." Science. ,vol. 159, pp. 1070- 1078 ,(1968) , 10.1126/SCIENCE.159.3819.1070
E. Samuels, E. Szabadi, Functional neuroanatomy of the noradrenergic locus coeruleus: its roles in the regulation of arousal and autonomic function part I: principles of functional organisation. Current Neuropharmacology. ,vol. 6, pp. 235- 253 ,(2008) , 10.2174/157015908785777229
Chung K. Yeung, Mei Diao, Biji Sreedhar, Cortical arousal in children with severe enuresis. The New England Journal of Medicine. ,vol. 358, pp. 2414- 2415 ,(2008) , 10.1056/NEJMC0706528
Ewald Naumann, Dieter Bartussek, Walter Kaiser, Gabriele Fehm-Wolfsdorf, Vasopressin and cognitive processes: Two event-related potential studies Peptides. ,vol. 12, pp. 1379- 1384 ,(1991) , 10.1016/0196-9781(91)90223-C
Edward M Ornitz, Andrew T Russell, Gregory L Hanna, Patrik Gabikian, Jean-Guido Gehricke, Dale Song, Donald Guthrie, Prepulse inhibition of startle and the neurobiology of primary nocturnal enuresis Biological Psychiatry. ,vol. 45, pp. 1455- 1466 ,(1999) , 10.1016/S0006-3223(98)00205-4
DOMINIK MÜLLER, HELKE FLORKOWSKI, KERSTIN CHAVEZ-KATTAU, GÖRAN CARLSSON, PAUL EGGERT, The effect of desmopressin on short-term memory in children with primary nocturnal enuresis The Journal of Urology. ,vol. 166, pp. 2432- 2434 ,(2001) , 10.1016/S0022-5347(05)65609-1
Edwin J. Mikkelsen, Childhood Enuresis Archives of General Psychiatry. ,vol. 37, pp. 1139- 1144 ,(1980) , 10.1001/ARCHPSYC.1980.01780230057008
Tryggve Nevéus, Arne Stenberg, Göran Läckgren, Torsten Tuvemo, Jerker Hetta, Sleep of children with enuresis: a polysomnographic study. Pediatrics. ,vol. 103, pp. 1193- 1197 ,(1999) , 10.1542/PEDS.103.6.1193