Human presynaptic receptors.

摘要: Presynaptic receptors are sites at which transmitters, locally formed mediators or hormones inhibit facilitate the release of a given transmitter from its axon terminals. The interest in identification presynaptic has faded recent years and it may therefore be justified to give an overview their occurrence autonomic central nervous system; this review will focus on human tissues. Autoreceptors restrains further release, though some instances also increase release. Inhibitory autoreceptors represent typical example negative feedback; they tonically activated by respective endogenous and/or constitutively active. play role under pathophysiological conditions, e.g. limiting massive noradrenaline occurring during congestive heart failure. They can used for therapeutic purposes; e.g., α2-adrenoceptor antagonist mirtazapine is as antidepressant inverse histamine H3 receptor agonist pitolisant been marketed new drug treatment narcolepsy 2016. Heteroreceptors transmitters adjacent neurons, (e.g. endocannabinoids) adrenaline) release; subject tone. constipating effect sympathetic system antihypertensive clonidine related activation inhibitory α2-adrenoceptors postganglionic parasympathetic neurons. Part stimulating adrenaline stress facilitatory via β2-adrenoceptors.