Treating chemotherapy induced agranulocytosis with granulocyte colony-stimulating factors in a patient on clozapine.

摘要: Background Clozapine is reserved for overcoming treatment resistance in schizophrenia. Malignancy common schizophrenia; however, there limited evidence available on continuing clozapine with chemotherapy, both having hematological adverse effects. Objective To report a case the use of granulocyte colony-stimulating factor (G-CSF) conjunction and chemotherapy. Methods We searched PubMed any information G-CSF chemotherapy. We patient schizophrenia who developed B-cell lymphoma was treated chemotherapy consisting CHOP regimen, rituximab, methotrexate. He continued G-CSF. Results We did not find reports found series rechallenge clozapine-induced agranulocytosis mixed results. In our clozapine, white blood cell counts reduced by were successfully replenished filgrastim, G-CSF. Conclusions With risks psychosis relapse exacerbation discontinuing addition could be useful aid replenishing lost to whilst clozapine. However, further study needed this combination. Copyright © 2012 John Wiley & Sons, Ltd.