Regulation of DDAH1 as a Potential Therapeutic Target for Treating Cardiovascular Diseases

作者: Xiaoyu Liu , John Fassett , Yidong Wei , Yingjie Chen

DOI: 10.1155/2013/619207

关键词: Heart failureEndocrinologyMyocardial infarctionInternal medicineBile acidUrsodeoxycholic acidPharmacologyFarnesoid X receptorReceptorAsymmetric dimethylarginineMedicineNitric oxide

摘要: … Reduced NO bioavailability causes hypertension [5], coronary disease, atherosclerosis and aging… protein arginine methyltransferases- (PRMT-) 1 or PRMT-2. PRMT-1 can subsequently …

参考文章(70)
Stephan von Haehling, Joerg C. Schefold, Ewa A. Jankowska, Jochen Springer, Ali Vazir, Paul R. Kalra, Anja Sandek, Günter Fauler, Tatjana Stojakovic, Michael Trauner, Piotr Ponikowski, Hans-Dieter Volk, Wolfram Doehner, Andrew J.S. Coats, Philip A. Poole-Wilson, Stefan D. Anker, Ursodeoxycholic Acid in Patients With Chronic Heart Failure Journal of the American College of Cardiology. ,vol. 59, pp. 585- 592 ,(2012) , 10.1016/J.JACC.2011.10.880
Juha Sinisalo, Hannu Vanhanen, Pia Pajunen, Heikki Vapaatalo, Markku S. Nieminen, Ursodeoxycholic acid and endothelial-dependent, nitric oxide-independent vasodilatation of forearm resistance arteries in patients with coronary heart disease British Journal of Clinical Pharmacology. ,vol. 47, pp. 661- 665 ,(1999) , 10.1046/J.1365-2125.1999.00940.X
H RUETTEN, S DIMMELER, D GEHRING, C IHLING, A ZEIHER, Concentric left ventricular remodeling in endothelial nitric oxide synthase knockout mice by chronic pressure overload Cardiovascular Research. ,vol. 66, pp. 444- 453 ,(2005) , 10.1016/J.CARDIORES.2005.01.021
Rainer H Böger, Stefanie M Bode-Böger, Philip S Tsao, Patrick S Lin, Jason R Chan, John P Cooke, An endogenous inhibitor of nitric oxide synthase regulates endothelial adhesiveness for monocytes. Journal of the American College of Cardiology. ,vol. 36, pp. 2287- 2295 ,(2000) , 10.1016/S0735-1097(00)01013-5
Qingping Feng, Xiangru Lu, Amanda J Fortin, Anders Pettersson, Thomas Hedner, Robert L Kline, J Malcolm O Arnold, Elevation of an endogenous inhibitor of nitric oxide synthesis in experimental congestive heart failure Cardiovascular Research. ,vol. 37, pp. 667- 675 ,(1998) , 10.1016/S0008-6363(97)00242-3
Norman M. Olken, Yoichi Osawa, Michael A. Marletta, Characterization of the inactivation of nitric oxide synthase by NG-methyl-L-arginine: evidence for heme loss. Biochemistry. ,vol. 33, pp. 14784- 14791 ,(1994) , 10.1021/BI00253A017
Stephen J. Nicholls, Zeneng Wang, Robert Koeth, Bruce Levison, Brian DelFraino, Vladimir Dzavik, Owen W. Griffith, David Hathaway, Julio A. Panza, Steven E. Nissen, Judith S. Hochman, Stanley L. Hazen, Metabolic Profiling of Arginine and Nitric Oxide Pathways Predicts Hemodynamic Abnormalities and Mortality in Patients With Cardiogenic Shock After Acute Myocardial Infarction Circulation. ,vol. 116, pp. 2315- 2324 ,(2007) , 10.1161/CIRCULATIONAHA.107.693986
Wei Li, Seema Mital, Caroline Ojaimi, Anna Csiszar, Gabor Kaley, Thomas H. Hintze, Premature death and age-related cardiac dysfunction in male eNOS-knockout mice. Journal of Molecular and Cellular Cardiology. ,vol. 37, pp. 671- 680 ,(2004) , 10.1016/J.YJMCC.2004.05.005
Tonghuan Hu, Michael Chouinard, Amy L. Cox, Philip Sipes, Marialuisa Marcelo, James Ficorilli, Shuyu Li, Hong Gao, Timothy P. Ryan, M. Dodson Michael, Laura F. Michael, Farnesoid X Receptor Agonist Reduces Serum Asymmetric Dimethylarginine Levels through Hepatic Dimethylarginine Dimethylaminohydrolase-1 Gene Regulation Journal of Biological Chemistry. ,vol. 281, pp. 39831- 39838 ,(2006) , 10.1074/JBC.M606779200