Interleukin-12 and the host response to parasitic helminths; the paradoxical effect on protective immunity and immunopathology

摘要: In general, helminth infections are associated with the development of dominant Th2-mediated immune responses which may be host protective but can also cause immunopathology. Interleukin 12 (IL-12) is known to a potent inhibitor Th2 and as such it might expected have an important modulatory role in helminth-induced responses. this review, we discuss effect IL-12 on susceptibility infection, immunity immunopathology, context exposure range helminths including intestinal nematodes, filariae schistosomes. It apparent that effects complex beneficial well detrimental for host. The precise depends upon number factors type specific tissue involved inflammatory response.