Molecular Cloning and Expression of Mouse Placental Lactogen I Complementary Deoxyribonucleic Acid
作者： Peter Colosi , Frank Talamantes , Daniel I. H. Linzer
关键词: Molecular biology 、 Biology 、 Gene expression 、 Human placental lactogen 、 Placental lactogen 、 Expression vector 、 Amino acid 、 Peptide sequence 、 Complementary DNA 、 Nucleic acid sequence
摘要: The mouse midpregnancy lactogen or placental I (mPL-I) is encoded by a 1.0-kilobase mRNA that appears transiently during gestation, with maximal amounts accumulating in the placenta at day 10 of pregnancy. Several cDNA clones for mPL-I have been isolated from lambda gt11 expression library constructed 10-placental RNA. sequence indicates synthesized as 224 amino acid precursor, and secreted 194 glycosylated hormone. deduced highly homologous to known members PRL family mouse, hybridization analysis genome contains several genes. Introduction an vector into cultured cells results synthesis secretion protein recognized anti-mPL-I antiserum biologically active.
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