作者: Tanja Savukoski , Laura Mehtälä , Bertil Lindahl , Per Venge , Kim Pettersson
DOI: 10.1016/J.CLINBIOCHEM.2015.06.015
关键词: Troponin complex 、 Serum samples 、 Resistance training 、 Surgery 、 Troponin I 、 Myocardial infarction 、 Reference values 、 Medicine 、 Cardiac troponin 、 Internal medicine 、 Acute coronary syndrome
摘要: Abstract Background Whereas elevated cardiac troponin (cTn) concentrations i.e. above the 99th percentile of healthy reference population (recommended cutoff for diagnosis myocardial infarction) are well-documented in individuals after prolonged and/or intensive exercises such as marathons, data on less-strenuous sports scarce. Therefore, our aim was to investigate cTnI and cTnT release response recreational resistance training, here a single-bout 1-h kettlebell workout. Methods Serum samples were collected from 11 apparently volunteers previous day (pre-exercise), three hours class (post-exercise), next days later. The aliquoted analyzed with Abbott Laboratories' Architect high-sensitivity (hs)-cTnI assay (limit detection, LoD = 2 ng/L), 3 + 1-type free cTn-specific autoantibody interference (LoD = 3 ng/L) Roche Diagnostics' hs-cTnT (LoD = 5 ng/L). Results post-exercise cTn significantly higher than pre-exercise values (median 5.5–9.6 ng/L vs. 26 ng/L, n = 2) (> 14 ng/L, n = 4). returned baseline during follow-up. Conclusions Our study demonstrates abnormally cTns well-validated sensitive assays training. This confirms that different kinds physical activity yet another confounder may affect determination use values. exercise-associated changes should be carefully addressed part evaluation what is “normal cTn”.