Elevation of cardiac troponins measured after recreational resistance training.

作者: Tanja Savukoski , Laura Mehtälä , Bertil Lindahl , Per Venge , Kim Pettersson

DOI: 10.1016/J.CLINBIOCHEM.2015.06.015

关键词: Troponin complexSerum samplesResistance trainingSurgeryTroponin IMyocardial infarctionReference valuesMedicineCardiac troponinInternal medicineAcute coronary syndrome

摘要: Abstract Background Whereas elevated cardiac troponin (cTn) concentrations i.e. above the 99th percentile of healthy reference population (recommended cutoff for diagnosis myocardial infarction) are well-documented in individuals after prolonged and/or intensive exercises such as marathons, data on less-strenuous sports scarce. Therefore, our aim was to investigate cTnI and cTnT release response recreational resistance training, here a single-bout 1-h kettlebell workout. Methods Serum samples were collected from 11 apparently volunteers previous day (pre-exercise), three hours class (post-exercise), next days later. The aliquoted analyzed with Abbott Laboratories' Architect high-sensitivity (hs)-cTnI assay (limit detection, LoD = 2 ng/L), 3 + 1-type free cTn-specific autoantibody interference (LoD = 3 ng/L) Roche Diagnostics' hs-cTnT (LoD = 5 ng/L). Results post-exercise cTn significantly higher than pre-exercise values (median 5.5–9.6 ng/L vs.  26 ng/L, n = 2) (> 14 ng/L, n = 4). returned baseline during follow-up. Conclusions Our study demonstrates abnormally cTns well-validated sensitive assays training. This confirms that different kinds physical activity yet another confounder may affect determination use values. exercise-associated changes should be carefully addressed part evaluation what is “normal cTn”.

参考文章(17)
Harvey D. White, Pathobiology of Troponin Elevations Journal of the American College of Cardiology. ,vol. 57, pp. 2406- 2408 ,(2011) , 10.1016/J.JACC.2011.01.029
Rob Shave, Aaron Baggish, Keith George, Malissa Wood, Jurgen Scharhag, Gregory Whyte, David Gaze, Paul D. Thompson, Exercise-Induced Cardiac Troponin Elevation: Evidence, Mechanisms, and Implications Journal of the American College of Cardiology. ,vol. 56, pp. 169- 176 ,(2010) , 10.1016/J.JACC.2010.03.037
Enrique Serrano‐Ostáriz, Jose Luis Terreros‐Blanco, Alejandro Legaz‐Arrese, Keith George, Rob Shave, Pilar Bocos‐Terraz, S Izquierdo‐Alvarez, JL Bancalero, JM Echavarri, J Quilez, MT Aragonés, Luis Enrique Carranza‐García, The impact of exercise duration and intensity on the release of cardiac biomarkers. Scandinavian Journal of Medicine & Science in Sports. ,vol. 21, pp. 244- 249 ,(2011) , 10.1111/J.1600-0838.2009.01042.X
Hugo A. Katus, Andrew Remppis, Thomas Scheffold, Klaus W. Diederich, Wolfgang Kuebler, Intracellular compartmentation of cardiac troponin T and its release kinetics in patients with reperfused and nonreperfused myocardial infarction. American Journal of Cardiology. ,vol. 67, pp. 1360- 1367 ,(1991) , 10.1016/0002-9149(91)90466-X
Smita Duttaroy, Daniel Thorell, Lena Karlsson, Mats Börjesson, A single-bout of one-hour spinning exercise increases troponin T in healthy subjects. Scandinavian Cardiovascular Journal. ,vol. 46, pp. 2- 6 ,(2012) , 10.3109/14017431.2011.622783
Tanja Savukoski, Jenna Jacobino, Päivi Laitinen, Bertil Lindahl, Per Venge, Noora Ristiniemi, Saara Wittfooth, Kim Pettersson, Novel sensitive cardiac troponin I immunoassay free from troponin I-specific autoantibody interference Clinical Chemistry and Laboratory Medicine. ,vol. 52, pp. 1041- 1048 ,(2014) , 10.1515/CCLM-2013-1044
Tanja Savukoski, Tuomo Ilva, Juha Lund, Pekka Porela, Noora Ristiniemi, Saara Wittfooth, Kim Pettersson, Autoantibody prevalence with an improved immunoassay for detecting cardiac troponin-specific autoantibodies. Clinical Chemistry and Laboratory Medicine. ,vol. 52, pp. 273- 279 ,(2014) , 10.1515/CCLM-2013-0310
Alejandro Legaz-Arrese, Isaac López-Laval, Keith George, Juan José Puente-Lanzarote, Carmen Mayolas-Pi, Enrique Serrano-Ostáriz, Pablo Revilla-Martí, Diego Moliner-Urdiales, Joaquín Reverter-Masià, Impact of an endurance training program on exercise-induced cardiac biomarker release. American Journal of Physiology-heart and Circulatory Physiology. ,vol. 308, ,(2015) , 10.1152/AJPHEART.00914.2014
Tar Choon Aw, Xander M.R. van Wijk, Alan H.B. Wu, Allan S. Jaffe, Release of cardiac troponin using a high sensitivity assay after exercise: Type 2 acute myocardial infarction? Clinica Chimica Acta. ,vol. 446, pp. 6- 8 ,(2015) , 10.1016/J.CCA.2015.04.002
Heidi Hyytiä, Taina Heikkilä, Pirjo Hedberg, Tarja Puolakanaho, Kim Pettersson, Skeletal troponin I cross-reactivity in different cardiac troponin I assay versions. Clinical Biochemistry. ,vol. 48, pp. 313- 317 ,(2015) , 10.1016/J.CLINBIOCHEM.2014.12.028