The effect of adjuvant chemotherapy in resectable cholangiocarcinoma: A meta-analysis and systematic review.
作者： Ming-Liang Wang , Zhang-Yan Ke , Shuai Yin , Chen-Hai Liu , Qiang Huang
DOI: 10.1016/J.HBPD.2018.11.001
关键词: Retrospective cohort study 、 Oncology 、 Medicine 、 Randomized controlled trial 、 Internal medicine 、 Chemotherapy regimen 、 Resectable Cholangiocarcinoma 、 Cochrane Library 、 Meta-analysis 、 Hazard ratio 、 Chemotherapy
摘要: Abstract Background The benefit of adjuvant chemotherapy for resectable cholangiocarcinoma remains unclear due to the lack randomized control studies. This study aimed investigate possible postoperative cholangiocarcinoma. Data sources Relevant research articles published before 1st March 2018 in PubMed, Embase and Cochrane library databases were retrieved. Published data extracted analyzed by RevMan 5.3, results presented as hazard ratios (HRs) [95% confidence intervals (CI)] forest plots. Results One prospective eighteen retrospective studies included, with a total number 11,458 patients, 4696 whom received chemotherapy. There was significant improvement overall survival (OS) patients who underwent operation + adjuvant compared those operation alone (HR = 0.61; P Conclusions Postoperative can improve OS intrahepatic hilar patients. However, distal gain no from Prospective trials are warranted order define standard regimen.
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