Downregulation of CD28 surface antigen on CD4+ and CD8+ T lymphocytes during HIV-1 infection.

摘要: A progressive significant decrease of CD28 surface antigen expression on CD4+ (mean, 90, 86, 79, 68% in stages I, II, III, and IV, respectively, versus 96% normals), as well CD8+ T lymphocytes 38, 32, 31, 29% 47% normals) was observed during HIV-1 infection. The increase cytotoxic/suppressor cells, both percentage absolute numbers, that almost all patients, associated with an the cells lacking antigen. loss parallel to CD38, human leukocyte (HLA)-DR, CD45RO throughout disease. Furthermore, a positive correlation within but not subset between expressing HLA-DR CD38 antigens, finding suggesting may be T-lymphocyte activation. Patients treated zidovudine showed no differences percentages either CD4+CD28+ or CD8+CD28+ T-cell subsets when compared untreated patients. These phenotypic changes functional defects infected individuals.