Omega-3 Fatty Acids in the Prevention of Interferon-Alpha-Induced Depression: Results from a Randomized, Controlled Trial

摘要: Background Interferon (IFN)-α therapy for chronic hepatitis C virus infection is frequently associated with depression. The routine prophylaxis antidepressants might expose patients to adverse effects, hence, the need alternative preventive interventions. Omega-3 polyunsaturated fatty acids are safe and effective essential nutritional compounds used treatment of depression, putatively through an anti-inflammatory action. In addition, lower erythrocyte levels omega-3 have been increased risk IFN-induced Methods We conducted a 2-week, double-blind, placebo-controlled trial comparing eicosapentaenoic acid (EPA), docosahexaenoic (DHA), placebo prevention IFN-α-induced A total 162 consented participate were randomized study. All completed 2-week trial; 152 participants followed throughout 24 weeks IFN-α included in analysis. Results Compared placebo, incident rates depression significantly EPA-treated but not DHA-treated (10% 28%, respectively, versus 30% p = .037). Both EPA DHA delayed onset (week onset: 12.0 11.7, 5.3 .002). both well tolerated this population. levels, only levels. Conclusions received therapy. Our study confirms notion that strategies context inflammation.